Tumour sink effect on 68Ga-PMSA PET/CT: A case of diffuse metastatic disease of prostate cancer

Authors

  • Sharjeel Usmani Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.
  • Khulood Al Riyami Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.
  • Sofiullah Abubakar Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman
  • Anjali Jain Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.
  • Asiya Al Busaidi Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.

DOI:

https://doi.org/10.47391/JPMA.23-45

Keywords:

68Ga-PSMA PET/CT, tumor sink effect, 177Lu-PSMA-RLT, PET/CT

Abstract

68Ga-PMSA imaging has revolutionized both diagnosis and radioligand therapy selection in patients with metastatic prostate cancer. We report a case of a 59-year-old recently diagnosed prostate cancer with high PSA level pf >2000ng/ml referred for 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT showed diffuse intense tracer uptake throughout the axial and appendicular skeleton with significantly lower uptake of 68Ga-PSMA in normal organs in a configuration of “tumour sink effect”. Findings are in keeping with diffuse skeletal infiltration and suspected marrow infiltration. Given the extensive nature of bone disease and pattern, 177Lu-PSMA-targetted radioligand therapy was thought to be more appropriate in a given situation with a favourable toxicity profile.

Keywords: 68Ga-PSMA PET/CT; tumor sink effect; 177Lu-PSMA-RLT; PET/CT

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Published

2023-05-15

How to Cite

Sharjeel Usmani, Khulood Al Riyami, Sofiullah Abubakar, Anjali Jain, & Asiya Al Busaidi. (2023). Tumour sink effect on 68Ga-PMSA PET/CT: A case of diffuse metastatic disease of prostate cancer. Journal of the Pakistan Medical Association, 73(6), 1344–1345. https://doi.org/10.47391/JPMA.23-45

Issue

Vol. 73 No. 6 (2023): JUNE

Section

IMAGING CORNER

License

Copyright (c) 2023 Journal of the Pakistan Medical Association

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This work is licensed under a Creative Commons Attribution 4.0 International License.