Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio

Authors

  • Sana Akhlaq Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan.
  • Saba Khaliq Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan.

DOI:

https://doi.org/10.47391/JPMA.10405

Keywords:

Wnt signalling pathway, Frizzled related protein 4, Diabetes mellitus, Type 2, Insulin resistance, Waist-height ratio, Blood glucose, Insulin, Waist circumference, Mass screening, Cross-sectional studies, Family, NAFLD, Metabolic syndrome

Abstract

The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein-4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist-to-height ratio values. Those without a diabetic background had significantly higher frizzled related protein-4 levels (p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist-to-height ratio, these differences were not statistically significant (p>0.05). However, there was a strong positive correlation with waist circumference, waist-to-height ratio, fasting insulin and homeostasis model of assessment of insulin resistance (p=0.0001).

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Author Biography

Saba Khaliq, Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan.

Supervisor

Published

2024-06-28

How to Cite

Sana Akhlaq, & Saba Khaliq. (2024). Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio. Journal of the Pakistan Medical Association, 74(7), 1338–1341. https://doi.org/10.47391/JPMA.10405

Issue

Section

Short Report