Prognostic Value of BRAF Mutation in Glioblastoma

Authors

  • Ayesha Sohail Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan.
  • Qurat-Ul-Ain Virani Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan.
  • Hafiza Fatima Aziz Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan.
  • Muhammad Shahzad Shamim Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan.

DOI:

https://doi.org/10.47391/JPMA.24-05

Abstract

With advances in molecular genetics, exploring targetable mutations for treating glioblastoma (GBM) patients, has become a centre of interest in modern day neuropathology. BRAF mutation has been extensively reported in several brain tumours. Recent studies report identification of BRAF mutation in GBM patients, especially isocitrate dehydrogenase wildtype glioblastomas (IDH-WT GBM), and its potential role in patient outcomes. Here we discuss the existing literature on the prognostic value of BRAF mutation in GBM.

Keywords: Glioblastoma, BRAF mutation, prognosis

Published

2023-12-24

How to Cite

Ayesha Sohail, Qurat-Ul-Ain Virani, Hafiza Fatima Aziz, & Muhammad Shahzad Shamim. (2023). Prognostic Value of BRAF Mutation in Glioblastoma. Journal of the Pakistan Medical Association, 74(1), 185–186. https://doi.org/10.47391/JPMA.24-05

Issue

Section

EVIDENCE BASED NEURO-ONCOLOGY

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