The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B

Authors

  • Habip Gedik Department of Infectious Disease and Clinical Microbiology, University of Health Sciences and Ministry of Health, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
  • Muge Sonmezisik Department of Infectious Disease and Clinical Microbiology, University of Health Sciences and Ministry of Health, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey

DOI:

https://doi.org/10.47391/JPMA.1135

Abstract

Abstract

We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the Department of Infectious Diseases and Clinical Microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in naïve patients with a partial response to TDF monotherapy.

Keywords: Chronic hepatitis B, Tenofovir, partial response, Entecavir, combination therapy

Published

2020-10-05

How to Cite

Gedik, H. ., & Muge Sonmezisik. (2020). The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B. Journal of the Pakistan Medical Association, 1-12. https://doi.org/10.47391/JPMA.1135

Issue

Section

Case Report