impact of diabetes mellitus on clinico-laboratory characteristics and in-hospital clinical outcomes among patients with myocardial

Authors

  • Syed Haroon Khalid Department of Pharmaceutics, Government College University, Faisalabad, Pakistan
  • Iqra Liaqat Faisalabad Institute of Cardiology FIC, Civil Lines, Faisalabad, Pakistan
  • Tauqeer Hussain Mallhi Department of Pharmacy Practice, Government College University, Faisalabad, Pakistan
  • Amer Hayat Khan Department of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia
  • Junaid Ahmad Chronic Kidney Disease Resource Center, Hospital University Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • Yusra Habib Khan Institute of Pharmacy, Lahore College for Women University, Lahore, Pakistan

DOI:

https://doi.org/10.47391/JPMA.370

Abstract

Abstract

Objective: Diabetes mellitus (DM) along with myocardial infarction (MI) carries increased burden on patients in terms of morbidity, mortality and cost. Current study was aimed to investigate the impact of DM on clinico-laboratory characteristics on in-hospital treatment outcomes among MI patients.

Methodology: All MI patients admitted to the emergency department of Faisalabad Institute of Cardiology from April, 2016 to March, 2017 were recruited into the study. The clinico-laboratory profile and in-hospital outcomes of patients with and without DM were compared using chi-squared test or student t-test, where appropriate.

Results: A total 4063 patients (Mean age: 55.86 ± 12.37years) with male preponderance were included into the study. STEMI was most prevalent (n = 2723, 67%) type of MI among study participants. DM was present in substantial number of cases (n = 3688, 90.8%). Patients with DM presented with increased BMI, higher blood pressure, elevated levels of cholesterol, serum creatinine, and blood urea nitrogen, when compared to the patients without DM (p<0.05). Out of 560 patients who were followed up, cardiogenic shock was frequent (n = 293, 52.3%) adverse outcome followed by heart failure (n = 114, 20.4%), atrial fibrillation (n = 78, 13.9%) and stroke (n = 75, 13.4 %). Moreover, in-hospital adverse outcomes were more prevalent among MI patients with DM than those without DM.

Conclusion: MI patients with DM present with varying clinico-laboratory characteristics as well as experience higher prevalence of adverse cardiovascular events as compared to patients without DM.

Continuous...

Published

2020-10-14

How to Cite

Syed Haroon Khalid, Iqra Liaqat, Tauqeer Hussain Mallhi, Amer Hayat Khan, Junaid Ahmad, & Yusra Habib Khan. (2020). impact of diabetes mellitus on clinico-laboratory characteristics and in-hospital clinical outcomes among patients with myocardial . Journal of the Pakistan Medical Association, 1-20. https://doi.org/10.47391/JPMA.370

Issue

Section

Research Article