Association of vitamin D levels with preeclampsia

Authors

  • Sana Shahid Sir Syed Medical College, Karachi, Pakistan
  • Asma Ladak 3rd Year Medical Student, Medical College, Aga Khan University, Karachi, Pakistan
  • Syeda Sadia Fatima Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
  • Fatima Abid Zaidi 4 Jinnah Sindh Medical University, Karachi, Pakistan
  • Sabah Farhat Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.414

Abstract

Abstract

Objectives: This study was aimed to assess maternal vitamin D status during pregnancy and  determine the association between maternal 25(OH) D levels with risk of preeclampsia (PE).

Methods: A cross-sectional study was conducted with 172 pregnant women recruited from JPMC between January and December 2017 who were divided as normotensive (n=80) and pre-eclamptic (n=92) groups. Blood pressure was recorded at 20 and 32 weeks of gestation. Five ml of blood sample was collected at 20 weeks of gestation to assess the vitamin D levels by commercially available ELISA assay.

Results:  PE group had a significantly higher systolic (p<0.001) and diastolic (p<0.001) blood pressure at 20 weeks of gestation. Vitamin D levels were reported to be significantly lower (p<0.001) in the PE group (17.97±9.38 ng/ml) as compared to normotensive group (42.18±25.17 ng/ml). A strong negative correlation of Vitamin D levels with systolic blood pressure (r=-0.428; p<0.001) and diastolic blood pressure (r= -0.375; p<0.001) was found.

Conclusion: This study found a strong relationship between low vitamin D levels and pre-eclamptic manifestation.

Keywords: Vitamin D; Pre-eclampsia; Pregnancy; Hypertension.

Continuous....

Published

2020-10-15

How to Cite

Sana Shahid, Asma Ladak, Syeda Sadia Fatima, Fatima Abid Zaidi, & Sabah Farhat. (2020). Association of vitamin D levels with preeclampsia. Journal of the Pakistan Medical Association. https://doi.org/10.47391/JPMA.414

Issue

Section

Research Article