Childhood core binding factor (CBF) acute myeloid leukemia and its association with French American British (FAB) classification

Authors

  • Naeem Jabbar Department of Pediatric Hematology Oncology, The Indus Hospital, Karachi, Pakistan
  • Neelum Mansoor Department of Hematology, The Indus Hospital, Karachi, Pakistan;
  • Sidra Maqsood Department of Pediatric Hematology Oncology, The Indus Hospital, Karachi, Pakistan;
  • Zaid Muhammad Aslam 4th Year MBBS Student, Ziauddin Medical University Hospital, Karachi, Pakistan
  • Anzal Taufeeq Jangda 4th Year MBBS Student, Ziauddin Medical University Hospital, Karachi, Pakistan
  • Syed Ahmer Hamid Department of Pediatric Hematology Oncology, The Indus Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.521

Abstract

Abstract

Objective: To find the frequency of core binding factor acute myeloid leukaemia in our population, and to determine its association with morphological subtypes.

Methods: The retrospective study was conducted at The Indus Hospital, Karachi, and comprised data of patients aged 1-17 years who were diagnosed with acute myeloid leukaemia from July 2013 to June 2017. Data was analysed using SPSS 21.

Results: Of the 237 patients, 137(58%) were males and 100(42%) were females. The overall mean age was 8±4.34 years. Cytogenetic testing had been performed in 212(89.45%) cases, and core binding factor was detected in 72(34%) cases. There was significant difference between the mean values of white cell count and the subtypes (p=0.000). Also the difference between core binding factor and the subtypes was significant (p=0.000).

Conclusion: There was found to be a significant association of core binging factor with specific subgroups of acute myeloid leukaemia.

Key Words: Acute myeloid leukaemia, Core binding factor, Cytogenetic abnormalities, Prognosis. Continuous....

Published

2020-10-17

How to Cite

Naeem Jabbar, Neelum Mansoor, Sidra Maqsood, Zaid Muhammad Aslam, Anzal Taufeeq Jangda, & Syed Ahmer Hamid. (2020). Childhood core binding factor (CBF) acute myeloid leukemia and its association with French American British (FAB) classification. Journal of the Pakistan Medical Association, 1-11. https://doi.org/10.47391/JPMA.521

Issue

Section

Research Article