Frequency and types of hemoglobinopathies in children with microcytic anemia

Authors

  • Sabeen Khan Department of Pediatrics, Shifa College of Medicne, Islamabad, Pakistan
  • Sahira Aaraj Department of Pediatrics, Shifa College of Medicne, Islamabad, Pakistan
  • Syeda Namayah Fatima Hussain Final Year Student, Shifa College of Medicine, Islamabad, Pakistan

DOI:

https://doi.org/10.47391/JPMA.589

Abstract

Abstract

Objective: To study the frequency and types of haemoglobinopathies in children with microcytic anaemia.

Method: The prospective study was conducted at the Paediatric Out-patient Department of Shifa Falahi Community Health Centre, Islamabad, Pakistan, from July to December, 2018, and comprised patients aged from 3 months to 14 years who had haemoglobin <10mg/dl and mean corpuscular volume <70fL. Serum ferritin and haemoglobin electrophoresis were done to check for iron deficiency anemia and haemoglobinopathies. Data was analysed using SPSS 23.

Results: Of 175 subjects, 33(18.9%) had haemoglobinopathies and 142(81.1%) had iron deficiency anaemia. Thalassemia trait 18(10.3%) was the leading cause amongst haemoglobinopathies, followed by thalassemia major 8(4.6 %) and intermedia 5(2.9%). There were 2(1.1%) patients with haemoglobin D.

Conclusion: The prevalence of hemoglobinopathies was high. Identification of haemoglobinopathies is important for proper treatment, antenatal screening and future genetic counselling.

Key Words: Haemoglobinopathy, Iron deficiency anaemia, Microcytic, MCV, IDA.

Published

2020-10-21

How to Cite

Khan, S., Sahira Aaraj, & Syeda Namayah Fatima Hussain. (2020). Frequency and types of hemoglobinopathies in children with microcytic anemia. Journal of the Pakistan Medical Association, 1-10. https://doi.org/10.47391/JPMA.589

Issue

Section

Research Article