Notch Signaling & Micro RNAs - two tumblers of neurogenesis and Gliomas

Authors

  • Zeeshan Javed Lahore Garrison University, Main Campus, Lahore, Pakistan
  • Qamar Raza Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
  • Faiez Ahmad Shah Quaid i Azam University, Islamabad, Pakistan
  • Haleema Sadia Department of Biochemistry, BUITEMS, Balochistan, Pakistan
  • Ayesha Alam Lahore Garrison University, Main Campus, Lahore, Pakistan
  • Faiza Anum Lahore Garrison University, Main Campus, Lahore, Pakistan
  • Mushtaq Ahmad Saleem University of Central Punjab, Lahore, Pakistan
  • Shahid Raza Department of Biotechnology, University of Central Punjab, Lahore, Pakistan

DOI:

https://doi.org/10.47391/JPMA.339

Abstract

Abstract

Gliomas are one of the most annihilating types of brain tumors having a high rate of annual incidence worldwide. Notch signaling is an evolutionary conserved pathway that regulates differentiation and development. Aberrations in Notch signalling pathways lead to severe pathological state such as the Gliomas. MicroRNAs (miRNAs) are the tiny molecules less than 200 bps in length and regulate a myriad of cellular processes. Categorically, miRNAs are divided in to oncogenic and tumor suppressor miRNAs. Accumulating data have identified miRNAs, which positively or negatively regulate Notch signaling in Gliomas. Here, we have assessed status of our understanding of the interplay between miRNA-base regulation of Notch signaling in gliomas, interaction between Notch signaling and other signaling cascades and have also discussed use of natural compounds that will help us get closer to personalized medicine for gliomas.

Keywords: Notch signaling; MicroRNA; Therapeutic Targets; Continuous...

Published

2020-11-03

Issue

Section

Narrative Review