Gastroenteropancreatic neuroendocrine tumors: clinicopathological evaluation at Shifa International Hospital, Islamabad. A single centre experience

Authors

  • Nadira Mamoon Department of Pathology, Shifa International Hospital, Islamabad, Pakistan
  • Hania Naveed Department of Pathology, Shifa College of Medicine, Shifa Tameer e Millat University, Islamabad, Pakistan
  • Mariam Abid Department of Histopathology, Aga Khan University Hospital, Karachi, Pakistan.
  • Humaira Nasir Department of Pathology, Shifa International Hospital, Islamabad, Pakistan
  • Imran Nazir Ahmad Department of Pathology, Shifa International Hospital, Islamabad, Pakistan
  • Zujajah Hameed Department of Pathology, Shifa International Hospital, Islamabad, Pakistan
  • Asna Haroon Khan Department of Pathology, Shifa International Hospital, Islamabad, Pakistan

DOI:

https://doi.org/10.47391/JPMA.835

Abstract

Abstract

Objective: Clinicopathological features of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have rarely been studied in the Pakistani population. We investigated the clinical characteristics of these tumors according to the updated World Health Organization (WHO) 2010 classification.

Methods: The data of Shifa International Hospital, Islamabad was retrospectively analysed for pathologically confirmed GEP-NETs from January 2013 to March 2018.

Results: One hundred and eighteen patients (mean age, 52.2 years; male, 55.1%) were identified. 83.1% of the patients were symptomatic including5.1% functional tumors. Pancreas (28%) was the most frequent primary site noted. The most common histologic type was well differentiated neuroendocrine tumor (WDNET) in 81.4% followed by neuroendocrine carcinoma (NEC) in 16.1%. 45.8% cases of WDNET were grade 1, 27.1% were grade 2, and 8.5% were grade 3.15.3% had distant metastasis at the time of diagnosis with liver (77.7%) as the most common metastatic site. Synaptophysin positivity was seen in 96.8% of grade 1 & grade 2 WDNET, 100% of grade 3 WDNET and 92.3% of NEC and chromogranin was positive in 94.2% of grade 1 &grade 2 WDNET, 83.3% of grade 3 WDNET and 45.4% of NEC.

Conclusion: GEP-NETs showed a wide clinicopathological spectrum. Pancreas is the most site of involvement by the GEP-NET however grade 3 WDNET had a predilection for the colon. Small cell carcinomas were commonly observed in esophagus.

Keywords: Gastroenteropancreatic neuroendocrine tu­mor, well differentiated neuroendocrine tumor, neuroendocrine carcinoma. Continuous...

Published

2020-11-03

How to Cite

Nadira Mamoon, Hania Naveed, Mariam Abid, Humaira Nasir, Imran Nazir Ahmad, Zujajah Hameed, & Asna Haroon Khan. (2020). Gastroenteropancreatic neuroendocrine tumors: clinicopathological evaluation at Shifa International Hospital, Islamabad. A single centre experience. Journal of the Pakistan Medical Association, 1-14. https://doi.org/10.47391/JPMA.835

Issue

Section

Audit