CRISPR Cas System: an efficient tool for cancer modelling

Authors

  • Mehran Akhtar Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan
  • Tazkira Jamal Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan
  • Mudassir Khan Department of Biotechnology, Atta ur Rahman School of Applied Biosciences, NUST, Islamabad, Pakistan
  • Shah Rukh Khan Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan
  • Shohra Haider Department of Biotechnology, Quaid-e-Azam University, Islamabad, Pakistan
  • Fazal jalil

DOI:

https://doi.org/10.47391/JPMA.801

Abstract

Abstract

The Clustered Regularly Interspaced Short Palindromic Repeats–Cas-9 (CRISPR-Cas9) system has been a revolutionising tool in the field of molecular genetics, which provides a versatile range of editing potentials. Researchers can produce breaks or alter genomes with ease using the system. Cancer is one of the multi-gene diseases whose genes need to be studied in detail. The CRISPR-Cas9 technology may also provide a promising potential in the field of cancer genetics. The current narrative review comprised 50 research articles which were keenly analysed and the applications and outcomes of CRISPR-Cas9 system in cancer genetics were comprehensively and critically discussed. It was concluded that application of the system had great potential to help understand cancer biology of various types and could be used for its genetic modelling. However, much work is still needed to be done to apply the technology for understanding...Continuous...

 

Published

2020-11-09

How to Cite

Mehran Akhtar, Tazkira Jamal, Mudassir Khan, Shah Rukh Khan, Shohra Haider, & Fazal jalil. (2020). CRISPR Cas System: an efficient tool for cancer modelling. Journal of the Pakistan Medical Association, 1-17. https://doi.org/10.47391/JPMA.801

Issue

Section

Narrative Review