Potential effect of sodium thiosulfate in calciphylaxis: remission of intractable pain

Authors

  • Canlin Yang Department of Nephrology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China
  • Yuqiu Liu Department of Nephrology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China
  • Haifeng Ni Department of Nephrology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China
  • Xiaomin Li Department of Clinical Pharmacy and Pharmacology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China
  • Hong Liu Department of Nephrology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China
  • Xiaoliang Zhang Department of Nephrology, Zhong Da Hospital, Affiliated to Southeast University School of Medicine, No.87, Dingjiaqiao, Gulou District, Nanjing, Jiangsu Province, China

DOI:

https://doi.org/10.47391/JPMA.1244

Abstract

Abstract

Calciphylaxis, a rare disease mainly seen in patients with chronic kidney disease, is characterised by ischaemic skin damages and excruciating pain. Calciphylaxis has poor prognosis which often results in amputation and high mortality. Although guidelines for the management of calciphylaxis are not available, sodium thiosulfate has showed efficacy in many clinical reports. We report the case of a 64-year-old advanced calciphylaxis male patient who had two amputations due to intolerable pain manifested as deteriorating ulcer. After he was treated with intravenous sodium thiosulfate (STS), his pain was significantly relieved with a healing trend of the big wound. One more amputation for the remission of intractable pain was avoided. The treatment experience indicates that sodium thiosulfate is of great value in quick pain relief and reducing suffering of calciphylaxis patients.

Keywords: Calciphylaxis, Calcific uremic arteriolopathy, Painful skin ulcer, Maintenance haemodialysis, Continuous....

Published

2020-11-12

Issue

Section

Case Report