Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein

Authors

  • Zhiming Jiang Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Hangzhou, China
  • Chenghui Li Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China
  • Hongyang Lu Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Hangzhou, China

DOI:

https://doi.org/10.47391/JPMA.1295

Abstract

Abstract

Objective: To analyse clinical and molecular features in patients with surgically resected patients with lung cancer harbouring anaplastic lymphoma kinase fusion.

Methods: The retrospective study was conducted at Zhejiang Cancer Hospital, Hangzhou, China, and comprised data from November 2013 to August 2015 of lung cancer patients. Anaplastic lymphoma kinase, epidermal growth factor receptor, kirsten rat sarcoma viral oncogene, v-raf murine sarcoma viral oncogene homolog, REarranged during Transfection proto-oncogene, c-ros oncogene 1 receptor kinase, V-Erb-B2 avian erythroblastic leukaemia viral oncogene homolog 2 and mesenchymal epithelial transition factor were noted using next generation sequencing. Clinicopathological parameters were also investigated. All patients were followed up till August 10, 2017. Data was analysed using SPSS 22.

Results: Of the 19 patients, 15(79%) were non-smokers. Anaplastic lymphoma kinase rearrangements occurred in the acinar predominant in 6(31.6%), Continuous...

 

 

Published

2020-11-17

How to Cite

Zhiming Jiang, Chenghui Li, & Hongyang Lu. (2020). Next generation sequencing detection in archival surgically resected lung adenocarcinoma specimens harboring the anaplastic lymphoma kinase fusion protein. Journal of the Pakistan Medical Association, 1-18. https://doi.org/10.47391/JPMA.1295

Issue

Section

Special Report