Clinical parameters and treatment outcome in patients of acromegaly: A retrospective analysis of 51 patients

Authors

  • Shahid Ahmed Department of Endocrinology, Hearts International Hospital, Rawalpindi, Pakistan
  • Ahmed Tashfeen Ashraf Department of Neurosurgery, Combined Military Hospital, Rawalpindi, Pakistan
  • Muhammad Junaid Mushtaq Department of Neurosurgery, Combined Military Hospital, Rawalpindi, Pakistan
  • Zujaja Hina Haroon Department of Chemical Pathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.2104

Abstract

The aim of the study was to analyze the pattern of clinical presentation and management outcome in patients of acromegaly. It is a cross-sectional study based on the clinical records of 51 patients of Acromegaly. All the recorded clinical data was analyzed to see the pattern of clinical presentation and management outcome. IBM SPSS statistics version 22 was used for statistical analysis. The median age was 32 years. Twenty seven patients underwent surgery and 6 (22.2%) achieved remission. With pharmacological management, 35.8% patients achieved control of the disease with Octreotide LAR and 7.1% with cabergoline. Eighteen patients were treated with External Beam Radiation (EBR) and Stereotactic Radiosurgery (SRS). Remission rate has been 88.9% with SRS and 33.3% with EBR. The study shows higher prevalence of Growth Hormone (GH) secreting tumour in younger people and men. Remission rate was highest in patients treated with radiotherapy after partial response to TSS.

Keywords: Acromegaly, trans-sphenoidal surgery, radiotherapy, Octreotide.

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Published

2022-04-01

How to Cite

Shahid Ahmed, Ahmed Tashfeen Ashraf, Muhammad Junaid Mushtaq, & Zujaja Hina Haroon. (2022). Clinical parameters and treatment outcome in patients of acromegaly: A retrospective analysis of 51 patients. Journal of the Pakistan Medical Association, 72(2), 346–348. https://doi.org/10.47391/JPMA.2104

Issue

Section

Research Article