The KgA1c Paradox: Widening the spectrum


  • Sanjay Kalra Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India;
  • Suneet Verma Department of Medicine, Alchemist Hospital, Panchkula, India;
  • Nitin Kapoor Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India; Non communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.



The term KgA1c paradox is used to describe the unwanted
rise in weight that occurs when HbA1c is controlled using
conventional therapy. We highlight facets of
pathophysiology, prevention, pharmacology, person
centred care, and epidemiology, which correspond to the
concept of KgA1c paradox. We suggest a novel index,
KgA1c product [(BMI) x (HbA1c)], which can be used to
evaluate efficacy of drugs, and assess metabolic control in
persons with diabetes,
Keywords: Diabesity, diabetes, HbA1c, metabolic
syndrome, overweight, obesity



How to Cite

Sanjay Kalra, Suneet Verma, & Nitin Kapoor. (2024). The KgA1c Paradox: Widening the spectrum. Journal of the Pakistan Medical Association, 74(7), 1378–1379.




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