Molecular imaging with 68Ga-PSMA PET/CT in high grade glioma: A biomarker for tumour neo-angiogenesis

Authors

  • Sharjeel Usmani Department of Radiology and Nuclear Medicine1, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman; Hull York Medical School, Hull, UK;
  • Khulood Al Riyami Department of Radiology and Nuclear Medicine1, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman;
  • Shah P Numani Department of Radiology, Carl T Hayden VA Medical Center, Phoenix USA;
  • Syed Furqan Hashmi Department of Radiology and Nuclear Medicine1, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman;
  • Anjali Jain Department of Radiology and Nuclear Medicine1, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman;
  • Rashid al Sukaiti Department of Radiology and Nuclear Medicine1, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman;
  • Najeeb Ahmed Hull York Medical School, Hull, UK;
  • Muhammad Shahzad Shamim Department of Surgery, Aga Khan University Hospital, Karachi Pakistan.

DOI:

https://doi.org/10.47391/JPMA.24-64

Abstract

There are several promising radiotracers used for both
staging and restaging of primary and recurrent brain
tumours based on various mechanisms of tracer
localization in tumour cells. 68Ga-PSMA PET has extremely
low background uptake in normal brain tissue and
consequently high tumour-to-brain ratio making it a
promising imaging radiotracer for gliomas. 68Ga-PSMA
demonstrates utility in evaluating high grade glioma
during both initial workup or when suspecting recurrence.
Herein the authors evaluate the role of this imaging
modality and the potential future it holds in the
management of high grade gliomas.
Keywords: 68Ga-PSMA; PET/CT; brain tumors; PET/CT;
gliomas; Glioblastoma Multiforme

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Published

2024-07-25

How to Cite

Sharjeel Usmani, Khulood Al Riyami, Shah P Numani, Syed Furqan Hashmi, Anjali Jain, Rashid al Sukaiti, Najeeb Ahmed, & Muhammad Shahzad Shamim. (2024). Molecular imaging with 68Ga-PSMA PET/CT in high grade glioma: A biomarker for tumour neo-angiogenesis. Journal of the Pakistan Medical Association, 74(8), 1552–1554. https://doi.org/10.47391/JPMA.24-64

Issue

Vol. 74 No. 8 (2024): AUGUST

Section

EVIDENCE BASED NEURO-ONCOLOGY

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Copyright (c) 2024 Journal of the Pakistan Medical Association

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