Very early onset inflammatory bowel disease (VEO-IBD); spectrum of clinical presentation, diagnostic tools and outcome in children

Authors

  • Huma Arshad Cheema Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan
  • Nadia Waheed Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan
  • Anjum Saeed Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan
  • Zafar Fayyaz Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan
  • Muhammad Nadeem Anjum Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan
  • Muhammad Arshad Alvi Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan
  • Syeda Sara Batool Department of Pediatric Medicine, The children's Hospital and Institute of Child Health, Lahore, Pakistan

DOI:

https://doi.org/10.47391/JPMA.05-725

Abstract

Background:

Very early-onset inflammatory bowel disease (VEO-IBD) is defined as diagnosis of Ulcerative Colitis (UC) or Crohn’s Disease (CD) in children under six years of age. Genome wide association studies have linked a strong genetic component responsible for VEO-IBD. Approximately, 30-40% children of VEO-IBD have underlying immunodeficiency states. We aimed to study the spectrum of presentation, underlying monogenetic defects and outcome in VEO-IBD.

Methods: This is a prospective, observational study conducted at division of Gastroenterology, the Children's Hospital & the Institute of Child Health, Lahore, over 2 years. Children developing features of IBD under six-years of age were included. Data included demography, clinical presentation, diagnostic tools and outcome. Gastroscopy and colonoscopy were performed in all patients in addition to basic work up done for associatedimmunodeficiency states and molecular genetics.  SPSS version 21 was used for analysis.

Continuous...

Published

2021-07-26

Issue

Section

Research Article