Chikungunya outbreak in Karachi Pakistan 2016-2017: an analysis of viral isolates

Authors

  • Dhani Prakoso Department of Comparative, Diagnostic, and Population Medicine University of Florida College of Veterinary Medicine, Florida, USA
  • Kelli Barr Department of Biology, Baylor University Waco, Texas, USA
  • Kehkashan Imtiaz Department of Pathology and Lab Medicine, Aga Khan University, Karachi, Pakistan
  • Joveria Farooqi Department of Pathology and Lab Medicine, Aga Khan University, Karachi, Pakistan
  • Erum Khan Department of Pathology and Lab Medicine, Aga Khan University, Karachi, Pakistan
  • Maureen Long Department of Comparative, Diagnostic and Population, College of Veterinary Medicine, University of Florida, Florida, USA
  • admin

DOI:

https://doi.org/10.47391/JPMA.1287

Abstract

Abstract

In December 2016 physicians in Karachi, Pakistan,witnessed an increase in patients presenting with febrile illness and severe polyarthralgia. Subsequently, chikungunya virus(CHIKV) was isolated from three patients. This virus was sequenced and compared with other isolates of CHIKVobtained in India and Pakistan during recent outbreaks. Phylogenetic analysis indicated that the Karachi isolates were most similar to the East Central South African CHIKV lineage and showed sequence homology to isolates obtained in other parts of Pakistan and India. More importantly, two of the CHIKV isolates had a nucleotide substitution in the E1 gene corresponding to an amino acid change at chain F portion of the E1 protein. Continuous...

Published

2020-12-26

How to Cite

Dhani Prakoso, Kelli Barr, Kehkashan Imtiaz, Joveria Farooqi, Erum Khan, Maureen Long, & admin. (2020). Chikungunya outbreak in Karachi Pakistan 2016-2017: an analysis of viral isolates. Journal of the Pakistan Medical Association, 1-11. https://doi.org/10.47391/JPMA.1287

Issue

Section

Short Communication / Short Report