Role of microRNAs in non-functioning pituitary adenoma

Authors

  • Mehak Rajani Centre for Innovation in Medical Education, The Aga Khan University, Karachi, Pakistan
  • Yumna Mirza Department of Surgery, The Aga Khan University, Karachi, Pakistan
  • Rohan Advani Final Year Medical Student, The Aga Khan University, Karachi, Pakistan
  • Syed Muhammad Adnan Ali Department of Surgery, The Aga Khan University, Karachi, Pakistan
  • Syed Ather Enam Department of Surgery, The Aga Khan University, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.3149

Abstract

Non-functioning pituitary adenomas account for 30% of anterior pituitary tumours. Based on their inability to secrete hormones, these are often diagnosed incidentally or due to pressure symptoms. Understanding the pathogenesis of these adenomas can provide insight into factors leading to its progression and serving as biomarkers for early recognition. A literature search was performed in the current narrative review for articles published in PubMed for the last 10 years till January 2020 on micro-ribonucleic acid involved in the pathogenesis of non-functioning pituitary adenomas. Of the 478 articles found, 21(4.4%) were filtered. In total, 106 micro-ribonucleic acids were identified, 25(23.5%) of which appeared in more than one study. Among them, 7(28%)were up-regulated, 11(44%) down-regulated, and 7(28%) were either up- or down-regulated. Micro- ribonucleic acids allow the screening, diagnosis and treatment of diseases in a relatively easy and inexpensive manner.

Continuous...

Published

2022-05-07

How to Cite

Rajani, M., Yumna Mirza, Rohan Advani, Syed Muhammad Adnan Ali, & Syed Ather Enam. (2022). Role of microRNAs in non-functioning pituitary adenoma. Journal of the Pakistan Medical Association, 72(01), 126. https://doi.org/10.47391/JPMA.3149

Issue

Section

Narrative Review

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