The Peptide Paradox in Pharmacology of Obesity

Abstract

Peptide biology is a fascinating subject, and peptide
pharmacology even more so. Peptides have multiple bodily
functions, including their work as hormones and metabolic
modulators. However, certain pharmacodynamic and
kinetic properties of peptides used in obesity result in
paradoxical outcomes. It is helpful for the treating clinician
to be aware of these peptide paradoxes, which not only
help in understanding the rationale of using these drugs
but also help to explain their differences in clinical actions.

Keywords: biological paradox, dual agonists, GIP receptor
agonists, GLP receptor agonists, glucagon agonists,
peptide biology, semaglutide, tirzepatide, triple agonists,