Obesity And The Spleen

Authors

  • Sanjay Kalra Department of Endocrinology, Bharti Hospital, Karnal, India; University Centre for Research & Development, Chandigarh University, Mohali, India
  • Suneet Kumar Vermaz Department of Medicine, Alchemist Hospital, Panchkula India; Sparsh Clinic, Panchkula, India
  • Nitin Kapoor Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India; Non communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

DOI:

https://doi.org/10.47391/JPMA.25-63

Abstract

This review describes the relationship of splenomegaly, or
“splenic obesity”, with metabolic syndrome, obesity and
metabolic – associated steatohepatic disease (MAFLD),
based on animal and human studies. The spleen is
enlarged in obesity. It may play a protective role against
obesity-associated inflammation and complications. This
protection may be lost after splenomegaly. Persons with
splenic disease must be evaluated for obesity, and vice
versa and counselled to avoid injury to the organ.
Keywords: MASLD, NAFLD, obesity, overweight, portal
hypertension, spleen, splenectomy, weight

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Published

2025-07-28

How to Cite

Sanjay Kalra, Suneet Kumar Vermaz, & Nitin Kapoor. (2025). Obesity And The Spleen. Journal of the Pakistan Medical Association, 75(8), 1298–1300. https://doi.org/10.47391/JPMA.25-63

Issue

Vol. 75 No. 8 (2025): AUGUST

Section

BAROCRINOLOGY

License

Copyright (c) 2025 Journal of the Pakistan Medical Association

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This work is licensed under a Creative Commons Attribution 4.0 International License.