Diagnostic accuracy of hematoxylin-eosin staining in comparison to calretinin and S100 for the assessment of ganglion cells in rectal biopsy

Authors

  • Zainab Waleed Aziz Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq https://orcid.org/0000-0002-0484-3553
  • Bassam Khalid Al Hajjar Department of Pediatric Surgery, College of Medicine, Mosul University, Mosul, Iraq
  • Ziyad Ahmed Abed Al Hajjar Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq
  • Ehsan Mahmood Abdullah Almola Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq
  • Nazar Mohammed Taher Jawher Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq
  • Radhwan Khudhur Muhammad Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

DOI:

https://doi.org/10.47391/JPMA.3368

Abstract

Objectives: To assess the diagnostic accuracy of haematoxylin-eosin staining in clinically suspected Hirschsprung disease, and to compare the findings with calretinin and S100 immunohistochemistry.

Method: The retrospective study was conducted at the AL-Khansaa Teaching Hospital, Nineveh, Iraq, and comprised data from January 2017 to October 2020 of rectal suction biopsies of patients with clinically and radiologically suspected Hirschsprung disease. Histopathology and immunohistochemistry were performed. Data was analysed using SPSS 16.

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Author Biographies

Zainab Waleed Aziz, Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

Senior Histopathologist in Medical College of Ninevah University

Bassam Khalid Al Hajjar, Department of Pediatric Surgery, College of Medicine, Mosul University, Mosul, Iraq

lecturer and senior pediatric surgeon, Department of pediatric surgery, College of Medicine, Mosul University, Mosul, Iraq

Ziyad Ahmed Abed Al Hajjar, Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

senior and lecturer histopathologist, Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq.

Ehsan Mahmood Abdullah Almola, Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

assistant prof. Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq.

Nazar Mohammed Taher Jawher, Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

assistant prof. Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

Radhwan Khudhur Muhammad, Department of Pathology, College of Medicine, Ninevah University, Mosul, Iraq

lecturer histopathologist Department of pathology, College of Medicine, Ninevah University, Mosul, Iraq.

Additional Files

Published

2022-01-25

Issue

Section

Research Article