Bridging Radiology and Pathology: ATRX Loss and T2-FLAIR Mismatch as Early Diagnostic and Prognostic Markers in Diffuse Gliomas

Authors

  • Quratulain Tariq Department of Neurosurgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
  • Eisha Abid Ali Medical Student, University College of Medicine and Dentistry, Lahore, Pakistan
  • Rahamah Arshad Medical Student, University College of Medicine and Dentistry, Lahore, Pakistan.
  • Ahmad Sohail Medical Student, University College of Medicine and Dentistry, Lahore, Pakistan.
  • Irfan Yousaf Department of Neurosurgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
  • Muhammad Shahzad Shamim Department of Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.

DOI:

https://doi.org/10.47391/JPMA.25-106

Abstract

ATRX mutation and the T2-FLAIR mismatch sign haveemerged as complementary molecular and imagingmarkers in diffuse gliomas. ATRX loss defines IDH-mutantastrocytoma at the molecular level, while the mismatchsign provides a non-invasive radiological clue with highspecificity but limited sensitivity. Used together, theyimprove diagnostic precision, refine prognosticassessment, and guide individualized treatmentplanning.

Keywords: ATRX mutation, T2-FLAIR mismatch sign,Astrocytoma, Oligodendroglioma

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Published

2025-11-22

How to Cite

Quratulain Tariq, Eisha Abid Ali, Rahamah Arshad, Ahmad Sohail, Irfan Yousaf, & Muhammad Shahzad Shamim. (2025). Bridging Radiology and Pathology: ATRX Loss and T2-FLAIR Mismatch as Early Diagnostic and Prognostic Markers in Diffuse Gliomas. Journal of the Pakistan Medical Association, 75(12), 1986–1989. https://doi.org/10.47391/JPMA.25-106

Issue

Vol. 75 No. 12 (2025): DECEMBER

Section

EVIDENCE BASED NEURO-ONCOLOGY

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Copyright (c) 2025 Journal of the Pakistan Medical Association

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