Association study of interleukin-1 receptor associated kinase 1 rs3027898 A?C gene polymorphism and preeclampsia in Pakistani population

Authors

  • Amna Mahmood Department of Biochemistry, Islamic International Medical College, Riphah University, Rawalpindi, Pakistan
  • Amena Rahim Department of Biochemistry, Islamic International Medical College, Riphah University, Rawalpindi, Pakistan
  • Muhammad Afzal Islamic International Medical College, Riphah University, Rawalpindi, Pakistan
  • Muhammad Imran Bajwa Department of Biochemistry, Islamic International Medical College, Riphah University, Rawalpindi, Pakistan
  • Yawar Zaman Punjab Employees Social Security Hospital, Islamabad, Pakistan
  • Hira Waqas Cheema Department of Anatomy, Islamic International Medical College, Riphah University, Rawalpindi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.1307

Abstract

Abstract

Objective: To find the association between interleukin- 1 receptor associated kinase 1 rs 3027898 gene polymorphism and preeclampsia in Pakistani population. Preeclampsia (PE) is defined as hypertension with proteinuria, diagnosed after 20 week of gestation up till 2 week postpartum. . It affects 2-8% of all pregnancies and remains a leading cause of maternal and perinatal deaths worldwide  with around  344,000  women  dying  from preeclampsia in the last ten years. Incidence of preeclampsia in pregnant women in Pakistan is 1.2%. The World Health Organization (WHO) estimates that preeclampsia is responsible for 12% of  maternal mortality in Asia. Continuous...

Published

2021-02-09

Issue

Section

Original Article