Evaluation of MONOFER-induced hypersensitive reactions: a retrospective cohort study

Authors

  • Mahreen Muzammil Department of Pharmacy, Aga Khan University, Karachi, Pakistan
  • Ainan Arshad Department of Internal Medicine, Aga Khan University, Karachi, Pakistan
  • Ahmed Ayaz Department of Internal Medicine, Aga Khan University, Karachi, Pakistan
  • Muhmmad Umair Ihsan Department of Pharmacy, Aga Khan University, Karachi, Pakistan
  • Kashif Hussain Department of Pharmacy, Aga Khan University, Karachi, Pakistan
  • Muhmmad Yasir Department of Medicine, Indus Hospital, Karachi, Pakistan
  • Hareem Rehman Department of Medicine, Aga Khan University, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.4940

Abstract

Iron deficiency is the most common cause of anaemia. Over the years, various IV preparations of iron have been developed, including Monofer® (Iron isomaltoside 1000), that showed a remarkable reduction in the occurance of hypersensitivity reactions. The main aim of the study was to evaluate the severity and extent to which hypersensitivity reactions occur after the administration of IV iron isomaltoside 1000 in an Asian population. Multistage sampling was adopted for this study. The overall sample size was 864. The mean age of the participants was 55.29 ±18.44 years. The results depicted that 63 (7.29%) of the entire participants faced hypersensitivity reactions after IV administration. A total of 43 (68.25%) of participants who experienced hypersensitivity reactions showed clinical symptoms within one hour, 11(17.46%) showed reaction in 1-3 hours and 9 (14.29%) showed in > 3 Hours.

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Published

2022-12-15

How to Cite

Mahreen Muzammil, Ainan Arshad, Ahmed Ayaz, Muhmmad Umair Ihsan, Kashif Hussain, Muhmmad Yasir, & Hareem Rehman. (2022). Evaluation of MONOFER-induced hypersensitive reactions: a retrospective cohort study. Journal of the Pakistan Medical Association, 73(1), 131–134. https://doi.org/10.47391/JPMA.4940

Issue

Section

Short Communication / Short Report

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