Methicillin resistant Staphylococcus aureus: A brief review of virulence and resistance

Methicillin resistant Staphylococcus aureus virulence and resistance

Authors

  • Ufaq Tasneem Department of Industrial Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan
  • Khalid Mehmood Department of Pharmacy, Abbottabad University of Science and Technology, Havelian, Pakistan
  • Mahnoor Majid Department of Industrial Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan
  • Sidra Rahmat Ullah Department of Industrial Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan
  • Saadia Andleeb Department of Industrial Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan

DOI:

https://doi.org/10.47391/JPMA.0504

Abstract

Staphylococcus aureus is a common gram-positive human pathogen involved in both community-acquired and nosocomial infections ranging from localized superficial lesions to food poisoning and fatal systemic infections owing to its impressive array of virulence factors responsible for attaching, colonizing, invading, and avoiding host immune system. The discovery of antibiotics effectively checked the once deadly infections. However, resistance started soon after their discovery and first methicillin resistant strain of S. aureus was reported in early sixties. The most important attribute of MRSA resistance to penicllins is its acquisition of mecA gene coding for penicillin-binding protein PBP2a that blocks inhibitory action on peptidoglycan cross-linking. Now MRSA presents a serious global healthcare concern being responsible for prolonged hospital stays and increased mortality. The precise information of virulence factors and resistant traits of MRSA and their interplay in a community is key to minimize the intermixing of resistant and susceptible pathogens in the community

Published

2022-02-03

How to Cite

Ufaq Tasneem, Khalid Mehmood, Mahnoor Majid, Sidra Rahmat Ullah, & Saadia Andleeb. (2022). Methicillin resistant Staphylococcus aureus: A brief review of virulence and resistance: Methicillin resistant Staphylococcus aureus virulence and resistance. Journal of the Pakistan Medical Association, 72(3). https://doi.org/10.47391/JPMA.0504

Issue

Section

Narrative Review