Long-term prognosis of culotte versus different crush strategies in management of unprotected left main bifurcation coronary lesions: a meta-analysis Authors Huaming Mou Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Li Yin Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Feng Zhu Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Shasha Li Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Jianming Zhang Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Xiaohua Pang Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Jianjun Yang Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Shimei Yu Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Yangjun Mou Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Doudou Wang Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China Hailong Wang Department of Cardiology, Heart Center, Chongqing University Three Gorges Hospital, China https://orcid.org/0000-0002-8565-6599 DOI: https://doi.org/10.47391/JPMA.5220 Abstract Objective: To assess the long-term clinical effects of Culotte and different Crush techniques in the treatment of unprotected left main bifurcation coronary lesions to determine the best percutaneous coronary intervention strategy. Method: The systematic review and meta-analysis comprised search on PubMed, Embase, Cochrane Library, WanFang Data and the China National Knowledge Infrastructure literature databases to locate randomised controlled trials and cohort studies published in Chinese and/or English language till June 2021 and comprised application of Culotte and Crush stenting techniques for percutaneous coronary intervention in patients with unprotected left main bifurcation coronary lesions. The selected studies were analysed for quality, publication bias and heterogeneity. Results: Of the 197 studies located, 8(4.06%) were subjected to meta-analysis. The incidence of major adverse cardiac events in the Mixed-Crush group was higher than the Culotte group (p=0.02), which, in turn, was higher than the Double Kiss Crush group (p<0.0001), The incidence of target lesion revascularisation in the Culotte group was significantly higher than Double Kiss Crush group (p<0.001). The incidence of myocardial infarction in the Culotte group was higher than the Double Kiss Crush group (p=0.04). The incidence of cardiogenic death in the Double Kiss Crush group was similar to that in the Culotte group (p=0.32). Conclusion: Patients in the Double Kiss Crush group had the most long-term benefits, while those receiving Mixed Crush had the least long-term benefits. Key Words: Culotte, Crush, Unprotected left main bifurcation coronary lesion, Meta-analysis, Systemic review. Downloads Full Text Article Published 2022-04-25 How to Cite Mou, H., Yin, L., Zhu, F., Li, S., Zhang, J., Pang, X., Yang, J., Yu, S., Mou, Y., Wang, D., & Hailong Wang. (2022). Long-term prognosis of culotte versus different crush strategies in management of unprotected left main bifurcation coronary lesions: a meta-analysis. Journal of the Pakistan Medical Association, 72(8), 1608–1614. https://doi.org/10.47391/JPMA.5220 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 8 (2022): AUGUST Section Meta-Analysis