Diagnostic value of bronchoscopy in Sars-Cov-2 infection: a systematic review

Authors

  • Hussain Ahmed Raza The Aga Khan University, Karachi, Pakistan
  • Mohummad Hassan Raza Raja 4th Year MBBS Student, The Aga Khan University, Karachi, Pakistan
  • Paul Arthur Bain Countway Library, Harvard Medical School, Boston, USA
  • Harmeet Bedi Department of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, USA
  • Rehana Salam Department of Paediatrics and Child Health, The Aga Khan University Hospital, Karachi, Pakistan
  • Bushra Jamil Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
  • Majid Shafiq Department of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

DOI:

https://doi.org/10.47391/JPMA.5668

Abstract

Objective: To investigate the diagnostic performance of bronchoscopy in patients with coronavirus disease 2019 infection.

Method: The systematic review was conducted in April 2021 and comprised search of published articles and preprint servers for original articles assessing diagnostic performance of bronchoscopy in patients with suspected coronavirus disease 2019 infection. The primary outcome of interest was diagnostic sensitivity of bronchoalveolar lavage in the patients The quality of each study was assessed using the Quality Assessment, Data Abstraction and Synthesis-2 tool.

Results: Of the 29 full-text articles assessed for eligibility, 4(13.8%) were included collectively comprising 209 patients who had undergone bronchoalveolar lavage. Mean sensitivity of bronchoalveolar lavage was 83.5% +/- 10.63 (range: 68.2-940%). Overall, the 4 studies had an unclear or low risk of bias.

Conclusion: Limited data suggested that bronchoscopy with bronchoalveolar lavage did not have reliably higher diagnostic sensitivity than that reported for either nasopharyngeal or oropharyngeal swabs.

Key Words: Bronchoscopy and interventional techniques, COVID-19, Diagnostic techniques.

Author Biography

Harmeet Bedi, Department of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, USA

Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA

Published

2022-12-15

Issue

Section

Systematic Reviews