Role of C- reactive proteins and liver function tests in assessing the severity of dengue fever

Authors

  • Akash Khetpal Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Ansab Godil Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Muhammad Tanveer Alam Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Inam ul Haq Muhammad Makhdoom Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Arsalan Majeed Adam Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Muhammad Saad Ali Mallick Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Mohammad Abubakar Abbas Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Abdul Haseeb Abbas Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Syed Saboor Hasan Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Asim Shaikh Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Hassan Ahmed Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Rohan Kumar Ochani Dow University of Health Sciences, Baba e Urdu Road, Karachi
  • Admin

DOI:

https://doi.org/10.47391/JPMA.170

Abstract

Abstract

Objective: To determine whether C-reactive protein and liver function tests can serve as severity markers for dengue fever.

Methods: The cross-sectional study was conducted in 2015-16 in Karachi and comprised patients with dengue fever visiting a tertiary care hospital. World Health Organisation classifications 1997 and 2009 were used to categorise patients according to clinical signs and symptoms. Receiver Operating Characteristics curve was used to determine discriminative ability and optimum cut-off value of biochemical markers. Comparisons were done through one-way analysis of variance using SPSS 17.

Results: Of the 218 patients, 133(61%) were males and 85(39%) were females. The overall mean age was 35.07+15.96 years. Levels of C-reactive protein and total bilirubin were significantly higher for dengue haemorrhagic fever compared to dengue fever; dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were significantly higher for dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of C-reactive protein, total bilirubin, alanine aminotransferase and alkaline phosphatise in patients with severe dengue were significantly higher compared to non-severe dengue.

Conclusion: C-reactive protein and liver function tests were found to be effective biochemical markers in assessing dengue fever severity.

Published

2020-12-07

How to Cite

Akash Khetpal, Ansab Godil, Muhammad Tanveer Alam, Inam ul Haq Muhammad Makhdoom, Arsalan Majeed Adam, Muhammad Saad Ali Mallick, Mohammad Abubakar Abbas, Abdul Haseeb Abbas, Syed Saboor Hasan, Asim Shaikh, Hassan Ahmed, Rohan Kumar Ochani, & Admin. (2020). Role of C- reactive proteins and liver function tests in assessing the severity of dengue fever. Journal of the Pakistan Medical Association, 1-17. https://doi.org/10.47391/JPMA.170

Issue

Section

Research Article