Intralesional bleomycin versus cryotherapy for treatment of cutaneous warts: a randomized controlled trial

Authors

  • Javaria Rahmatullah Jinnah Postgraduate Medical Centre, Karachi, Pakistan
  • Rabia Ghafoor Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
  • Muhammad Akhter Anwer Department of Statistics, Jinnah Postgraduate Medical Centre, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.6372

Keywords:

Cryotherapy, Cutaneous, Warts, Intralesional, Bleomycin, Randomised controlled trial

Abstract

Objective: To evaluate the effectiveness of intralesional bleomycin in comparison to cryotherapy in the treatment of cutaneous warts.

Method: The randomized controlled trial was conducted at the Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from January to July 2021, and comprised patients of either gender aged 18-60 years who had cutaneous warts for 1-48 weeks. The subjects were divided into group A treated with 0.1% intralesional bleomycin, and group B were treated with cryotherapy through non probability consecutive sampling. Follow-up examination was done at the 2, 4 and 6 weeks. Data was analysed using SPSS 23.

Result: Of the 154 patients, 96(62.3%) were male and 58(37.7%) were females. The overall mean age was 33.253+6.726 years. There were 77(50%) patients in each of the two groups. The therapy after 6 weeks was found to be effective 73(94.8%) group A patients and 57(74%) group B patients (p=0.001).

Conclusion: Intralesional bleomycin was found to be more successful than cryotherapy in the treatment of cutaneous warts.

Clinical Trial Link: https://clinicaltrials.gov RCT No. (NCT05023408)

Key Words: Cryotherapy, Cutaneous, Warts, Intralesional, Bleomycin, Randomised controlled trial.

Published

2023-09-13

How to Cite

Rahmatullah, J., Rabia Ghafoor, & Muhammad Akhter Anwer. (2023). Intralesional bleomycin versus cryotherapy for treatment of cutaneous warts: a randomized controlled trial. Journal of the Pakistan Medical Association, 73(10), 1949–1953. https://doi.org/10.47391/JPMA.6372

Issue

Section

Original Article