Intralesional bleomycin versus cryotherapy for treatment of cutaneous warts: a randomized controlled trial
Keywords:Cryotherapy, Cutaneous, Warts, Intralesional, Bleomycin, Randomised controlled trial
Objective: To evaluate the effectiveness of intralesional bleomycin in comparison to cryotherapy in the treatment of cutaneous warts.
Method: The randomized controlled trial was conducted at the Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from January to July 2021, and comprised patients of either gender aged 18-60 years who had cutaneous warts for 1-48 weeks. The subjects were divided into group A treated with 0.1% intralesional bleomycin, and group B were treated with cryotherapy through non probability consecutive sampling. Follow-up examination was done at the 2, 4 and 6 weeks. Data was analysed using SPSS 23.
Result: Of the 154 patients, 96(62.3%) were male and 58(37.7%) were females. The overall mean age was 33.253+6.726 years. There were 77(50%) patients in each of the two groups. The therapy after 6 weeks was found to be effective 73(94.8%) group A patients and 57(74%) group B patients (p=0.001).
Conclusion: Intralesional bleomycin was found to be more successful than cryotherapy in the treatment of cutaneous warts.
Clinical Trial Link: https://clinicaltrials.gov RCT No. (NCT05023408)
Key Words: Cryotherapy, Cutaneous, Warts, Intralesional, Bleomycin, Randomised controlled trial.
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