Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics

Authors

  • Muntaha Maqsood Department of Biochemistry and Molecular Biology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Palvasha Waheed Department of Biochemistry and Molecular Biology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Amir Rashid Department of Biochemistry and Molecular Biology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Asifa Majeed Department of Biochemistry and Molecular Biology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Ahsan Mukhtar Department of Vitero Retinal Surgery, Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.6382

Keywords:

AKR1B1, Diabetes mellitus, Diabetic retinopathy, Single nucleotide polymorphism

Abstract

Objective: To investigate the association of polymorphism in rs752010122 in aldose reductase gene with the pathogenesis of diabetic retinopathy, and to determine the association and allelic frequency between the variant and the disease.

Method: The cross-sectional study was conducted from June 2021 to March 2022 at Centre for Research in Experimental and Applied Medicine (CREAM) Laboratory, Department of Biochemistry and Molecular Biology, Army Medical College, in collaboration with the Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan, and comprised blood samples from subjects of either gender aged 40-70 years. The samples were divided into group I having diabetic retinopathy patients, group II having diabetics without retinopathy, and group III having healthy controls matched for age and gender.  The samples were subjected to molecular analysis

Results: Of the 150 subjects, there were 50(33.3%) in each of the 3 groups. Variants of aldose reductase rs752010122 polymorphism were significantly associated with a lower risk of diabetic retinopathy (p<0.05). An odds ratio of 1 was noted for both heterozygous and homozygous genotypes (95% confidence interval: 1).

Conclusion: Aldose reductase was associated with lower risk of the disease.

Key Words: AKR1B1, Diabetes mellitus, Diabetic retinopathy, Single nucleotide polymorphism.

Published

2023-04-15

Issue

Section

Research Article

Most read articles by the same author(s)