Stage IVa ovarian cancer one year following the third IVF procedure
Ovarian cancer is the second cause of gynecologic cancer death in senior women which is less common at reproductive age. We herein present an extremely rare case of a childless woman of secondary infertility diagnosed with stage IVa ovarian cancer just one year after the IVF cycle. A 37-year-old woman of secondary infertility for two years experienced three cycles of ovarian stimulation, two grade II cleavage-stage embryos transferred, did not result in pregnancy. During the IVF treatment, ovarian cyst puncture was performed and none of malignant cell observed. The following year she suffered from abdominal pain with extremely elevated tumor markers. Stage IVa ovarian carcinoma was confirmed by transabdominal operation. The patient underwent cytoreductive surgery and chemotherapy. However, late-stage ovarian cancer was insensitive to postoperative chemotherapy with poor CA125 declined. The case had aroused high attention among the security of IVF including standardization and closely long-term follow-up.