Understanding the pathogenesis of Graves’ orbitopathy: A new age paradigm Authors Deepthi Elizabeth Kurian Department of Ophthalmology, Schell eye hospital, Christian Medical College, Vellore ,India Sanjay Kalra CEO & Co-Founder, Fitterfly-Digital Health & Therapeutics, India. Nitin Kapoor Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore (TN) -632004, India, and Non Communicable Disease Unit, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. DOI: https://doi.org/10.47391/JPMA.22-28 Abstract Graves' orbitopathy or thyroid associated orbitopathy (TAO) is a disquieting condition both for the patient and the clinician. While the mainstay of treatment of the orbitopathy is corticosteroids, its action is non-specific. The arguments against its use also include multiple side effects and recurrence on stopping it. While some clinicians are complacent with the drug due to our long term experience with it, many are in search for specific so called 'targeted' treatment. The autoimmune process in TAO is rather complex where multiple cytokines act at more than one level making it challenging to control the inflammation. Hence, in order to discover better treatment strategies, having a sound understanding of the pathogenesis of the disease is essential. Keywords: Graves, Orbital fibroblasts, Autoimmunity. Continue... Downloads Full Text Article Published 2022-04-05 How to Cite Deepthi Elizabeth Kurian, Sanjay Kalra, & Nitin Kapoor. (2022). Understanding the pathogenesis of Graves’ orbitopathy: A new age paradigm. Journal of the Pakistan Medical Association, 72(4), 767–770. https://doi.org/10.47391/JPMA.22-28 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 4 (2022): APRIL Section RECENT ADVANCES IN ENDOCRINOLOGY