Comparison of potential plasma biomarkers in Alzheimer’s disease and neurodegenerative dementias in Pakistani population Authors Tehniat Faraz Ahmed Department of Biochemistry, Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan https://orcid.org/0000-0002-8240-6973 Fauzia Imtiaz Department of Biochemistry, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan Uzma Zaman Department of Biochemistry, Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan Affan Ahmed 3rd Year MBBS Student, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan https://orcid.org/0000-0002-7974-2730 Naila Shahbaz Department of Neurology, Civil Hospital, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.7286 Keywords: Biomarkers, Alzheimer disease, Amyloid beta peptides, Tau proteins, Neurofilament proteins Abstract This study aimed to compare the mean plasma levels of Amyloid B42, Phosphorylated Tau and Neurofilament Light chain in patients diagnosed with Alzheimer’s Clinical Syndrome (ACS), and other neurodegenerative dementias to find affordable and less-invasive means of diagnosing Alzheimer’s disease (AD) early in its course. Blood samples of 36 subjects presenting with cognitive decline to the neurology OPDs of Dow and Civil hospitals, Karachi, were centrifuged, and plasma was stored at 80C. Before analysis, it was thawed at 4C and protein levels were measured through ELISA. Two-thirds of the patients were females but age distribution across both the groups was not significantly different (p 0.21). No difference was observed in the mean plasma concentrations of AB42, P-Tau, and NFL between the two groups (p-values 0.78 and 0.27 and 0.09 respectively). ---Continue Downloads Full Text Article Published 2023-09-13 How to Cite Faraz Ahmed, T., Imtiaz, F., Zaman, U., Ahmed, A., & Shahbaz, N. (2023). Comparison of potential plasma biomarkers in Alzheimer’s disease and neurodegenerative dementias in Pakistani population. Journal of the Pakistan Medical Association, 73(10), 2062–2064. https://doi.org/10.47391/JPMA.7286 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 10 (2023): OCTOBER Section Short Communication License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.