Comparison of potential plasma biomarkers in Alzheimer’s disease and neurodegenerative dementias in Pakistani population

Authors

  • Tehniat Faraz Ahmed Department of Biochemistry, Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan https://orcid.org/0000-0002-8240-6973
  • Fauzia Imtiaz Department of Biochemistry, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
  • Uzma Zaman Department of Biochemistry, Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan
  • Affan Ahmed 3rd Year MBBS Student, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan https://orcid.org/0000-0002-7974-2730
  • Naila Shahbaz Department of Neurology, Civil Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.7286

Keywords:

Biomarkers, Alzheimer disease, Amyloid beta peptides, Tau proteins, Neurofilament proteins

Abstract

This study aimed to compare the mean plasma levels of Amyloid B42, Phosphorylated Tau and Neurofilament Light chain in patients diagnosed with Alzheimer’s Clinical Syndrome (ACS), and other neurodegenerative dementias to find affordable and less-invasive means of diagnosing Alzheimer’s disease (AD) early in its course.

Blood samples of 36 subjects presenting with cognitive decline to the neurology OPDs of Dow and Civil hospitals, Karachi, were centrifuged, and plasma was stored at 80C. Before analysis, it was thawed at 4C and protein levels were measured through ELISA.

Two-thirds of the patients were females but age distribution across both the groups was not significantly different (p 0.21). No difference was observed in the mean plasma concentrations of AB42, P-Tau, and NFL between the two groups (p-values 0.78 and 0.27 and 0.09 respectively).

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Published

2023-09-13

How to Cite

Faraz Ahmed, T., Imtiaz, F., Zaman, U., Ahmed, A., & Shahbaz, N. (2023). Comparison of potential plasma biomarkers in Alzheimer’s disease and neurodegenerative dementias in Pakistani population. Journal of the Pakistan Medical Association, 73(10), 2062–2064. https://doi.org/10.47391/JPMA.7286

Issue

Section

Short Communication / Short Report