Role of Lactobacillus plantarum 299v versus Placebo in symptomatic improvement of irritable bowel syndrome patients

Authors

  • Moeen-Ul-Haq Department of Gastroenterology, Gomal Medical College, Dera Ismail Khan, Pakistan
  • Ahmad Nawaz Babar Department of Gastroenterology, Madina Teaching Hospital, Faisalabad, Pakistan
  • Muhammad Kamran Hassan Department of Gastroenterology and Hepatology, Lady Reading Hospital, Peshawar, Pakistan
  • Fazl Ullah Department of Gastroenterology and Hepatology, Lady Reading Hospital, Peshawar, Pakistan
  • Anwar Ullah Institute of Paramedical Sciences, Khyber Medical University, Peshawar, Pakistan

DOI:

https://doi.org/10.47391/JPMA.0758

Abstract

Objective: To find the efficacy of lactobacillus plantarum 299v compared to placebo in symptomatic improvement of irritable bowel syndrome patients.

Method: The randomised control trial was conducted at the Lady Reading Hospital, Peshawar, Pakistan, from July 20, 2014, to January 20, 2015, and comprised irritable bowel syndrome patients who were randomised into intervention group A treated with lactobacillus plantarum 299v and control group B treated with placebo. Symptoms, like abdominal pain, bloating and complete rectal emptying, were noted and compared between the groups. Data was analysed using SPSS 19.

Results: Of the 190 patients assessed, 120(63%) were included; 60(50%) in each of the two groups. After loss to follow-up, the study was completed by 55(91.7%) in group A and 53(88.3%) in group B. The mean age in group A was 37.53 ± 9.02 and it was 34.40±11.23 in group B (p=0.652). The male-to-female ratio and irritable bowel syndrome type in both the groups was not significantly different (p>0.055). There was no significant difference in terms of relieving abdominal pain, bloating and rectal emptying between the groups (p>0.05).

Conclusion: No significant efficacy was established in favour of treating in irritable bowel syndrome with lactobacillus plantarum 299v.

Trials Registration: Registration number IRCT20200504047303N1

Key Words: IBS, Lactobacillus plantarum 299v, Placebo.

Published

2022-02-03

How to Cite

Moeen-Ul-Haq, Ahmad Nawaz Babar, Muhammad Kamran Hassan, Fazl Ullah, & Anwar Ullah. (2022). Role of Lactobacillus plantarum 299v versus Placebo in symptomatic improvement of irritable bowel syndrome patients. Journal of the Pakistan Medical Association, 72(3), 404–408. https://doi.org/10.47391/JPMA.0758

Issue

Section

Original Article

Most read articles by the same author(s)