Serum resistin and lipid profile in primigravida females with and without preeclampsia: an analytical cross-sectional study Authors Mehwish Rana Department of Physiology, Abu Umara Medical and Dental College, The Green International University, Lahore, Pakistan Mohsin Ali Cheema Department of Physiology, Abu Umara Medical and Dental College, The Green International University, Lahore, Pakistan Rida Ajmal khan Department of Physiology, Abu Umara Medical and Dental College, The Green International University, Lahore, Pakistan Asia Kanwal Department of Physiology, Shalamar Medical and Dental College, Lahore, Pakistan Arshia Mobeen Rana Department of Biochemistry, Allama Iqbal Medical College, Lahore, Pakistan Khalid Parvez Lone Department of Physiology, University of Health Sciences, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.8218 Keywords: Pre-eclampsia, Resistin, Hypertension, Pregnancy outcome, Primigravida Abstract Objective: To measure and compare the serum levels of resistin and lipid profile parameters in primigravida females with and without preeclampsia. Method: The analytical cross-sectional study was conducted at the Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan, from 2018 to 2020, and comprised primigravida females having gestational age 30-36 weeks. Those with preeclampsia constituted group 1, while normotensive females constituted group 2. All the participants were subjected to detailed history and general physical examination. Serum resistin levels were measured by enzyme-linked immunosorbent assay, and lipid profile parameters were measured using the colorimetric method. Data was analysed using SPSS 20. Results: Of the 80 women, 40(50percent) were in group 1 with mean age 23.07±2.10 years and mean gestation age 33.45±2.30 weeks. There were 40(50percent) women in group 2 with mean age 23.02±2.11 years and mean gestational age 34.45±1.75 weeks. Mean serum resistin was significantly higher in group 1 compared to group 2 (p 0.02). Mean levels of lipid parameters were significantly different between the groups (p 0.05). Conclusion: Preeclampsia was found to be associated with higher levels of resistin and lipid parameters compared to normal pregnancy. Keywords: Pre-eclampsia, Resistin, Hypertension, Pregnancy outcome, Primigravida. Author Biographies Mehwish Rana, Department of Physiology, Abu Umara Medical and Dental College, The Green International University, Lahore, Pakistan Senior Demostrtor of the Physiology Department. Mohsin Ali Cheema, Department of Physiology, Abu Umara Medical and Dental College, The Green International University, Lahore, Pakistan Professor and head of the department of Physiology. Rida Ajmal khan, Department of Physiology, Abu Umara Medical and Dental College, The Green International University, Lahore, Pakistan Assistant Professor of the Physiology Department. Asia Kanwal, Department of Physiology, Shalamar Medical and Dental College, Lahore, Pakistan Assistant Professor of Physiology department. Arshia Mobeen Rana, Department of Biochemistry, Allama Iqbal Medical College, Lahore, Pakistan Assistant Professor of biochemistry department. Downloads Full Text Article Published 2023-12-24 How to Cite Rana, M., Cheema, M. A., khan, R. A., Kanwal, A., Rana, A. M., & Khalid Parvez Lone. (2023). Serum resistin and lipid profile in primigravida females with and without preeclampsia: an analytical cross-sectional study. Journal of the Pakistan Medical Association, 74(1), 62–66. https://doi.org/10.47391/JPMA.8218 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 1 (2024): JANUARY Section Research Article License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.