Dengue fever presenting as acute febrile illness in neonates: a case series from Pakistan

Authors

  • Maliha Salim Department of Pediatrics, Aga Khan University Hospital, Karachi, Pakistan
  • Vinod Kumar Department of Pediatrics, Aga Khan University Hospital, Karachi, Pakistan
  • Hafsa Zaheer Department of Pediatrics, Aga Khan University Hospital, Karachi, Pakistan
  • Nazia Shamim Department of Pediatrics, Aga Khan University Hospital, Karachi, Pakistan
  • Hina Mumtaz Hashmi Department of Pediatrics, Aga Khan University Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.8260

Keywords:

Neonate, dengue fever, thrombocytopenia, dengue haemorrhagic fever, dengue shock syndrome

Abstract

Dengue fever is a mosquito-borne disease caused by flavivirus. It primarily infects people living in tropical and subtropical areas and can be transmitted vertically or horizontally to new-borns. We discuss the clinical spectrum, treatment, and outcomes of five neonates who presented with dengue fever at Aga Khan Hospital for Women in Karimabad, Karachi, Pakistan, during the 2021 post-monsoon season (October to December). Dengue infection was confirmed via positive NS1 antigen test. All new-borns had fever, flushing, and thrombocytopenia. Capillary leak syndrome and haemorrhagic complications occurred in one case. Two babies required oxygen support, with one mortality. Due to the severity of the disease in this population, we suggest that dengue fever should be evaluated as a differential diagnosis in neonates with sepsis and thrombocytopenia, especially in high-risk or endemic areas.

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Published

2023-09-13

How to Cite

Salim, M., Kumar, V., Zaheer, H., Shamim, N., & Hashmi, H. M. (2023). Dengue fever presenting as acute febrile illness in neonates: a case series from Pakistan. Journal of the Pakistan Medical Association, 73(10), 2103–2107. https://doi.org/10.47391/JPMA.8260

Issue

Section

Case Series