Prevalence and risk factors of sarcopenia in patients with cirrhosis – an observational study

Authors

  • Ammara Abdul Majeed National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan
  • Hafeezullah Shaikh National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan
  • Abdur Rasheed School of Public Health, Dow University of Health Sciences, Karachi, Pakistan
  • Raheela Khalid National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan
  • Fakhar Ali Qazi Arisar National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan
  • Hafsa Ghias National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.8461

Keywords:

End-stage liver disease, Hand strength, Frailty, Potassium, Serum albumin

Abstract

Objectives: To identify the prevalence and predictors of sarcopenia in cirrhotic patients.

Method: The observational, cross-sectional study was conducted at the National Institute of Liver and Gastrointestinal Diseases, Karachi, from January 30 to July 31, 2021, and comprised cirrhotic patients of either gender aged 18-60 years. Clinical and laboratory data was recorded for each patient. Body weight was adjusted for ascites. Sarcopenia was determined based on the Asian Working Group for Sarcopenia-2019 guideline via hand grip strength and chair standing. Independent predictors for sarcopenia were identified. Data was analysed using SPSS 26.

Results: Out of 434 cirrhotic patients assessed, 386(89%) were enrolled. Of them, 237(61.4%) were males, 149(38.6%) were females, 327(84.7%) were aged >45 years and 201(52.1%) had moderate professional activity. Sarcopenia was detected in 314(81.3%) patients; 185(59%) males and 129(41%) females. Age, chair exercise and hand grip scores as well as haemoglobin, albumin and potassium levels were significantly associated with sarcopenia (p<0.05)

Conclusion: Sarcopenia was found to be very common in patients with cirrhosis. Increasing age, concomitant comorbidities, and presence of liver decompensation increased the risk of sarcopenia.

Key Words: End-stage liver disease, Hand strength, Frailty, Potassium, Serum albumin.

Author Biographies

Hafeezullah Shaikh, National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan

Assistant professor , NILGID, Dow University Hospital

Abdur Rasheed, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan

Assistant professor, School of Public Health, Dow University of Health Sciences

Fakhar Ali Qazi Arisar, National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan

Assistant professor , NILGID, Dow University Hospital

Hafsa Ghias, National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan

House officer at NILGID

Published

2023-09-13

How to Cite

Abdul Majeed, A., Hafeezullah Shaikh, Abdur Rasheed, Raheela Khalid, Fakhar Ali Qazi Arisar, & Hafsa Ghias. (2023). Prevalence and risk factors of sarcopenia in patients with cirrhosis – an observational study. Journal of the Pakistan Medical Association, 73(10), 2004–2008. https://doi.org/10.47391/JPMA.8461

Issue

Section

Research Article