Usual presentation of an unusual pathogen – Cryptococcus laurentii meningitis: a case report

Authors

  • Azka Zulfiqar Department of Microbiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Rafia Irfan Department of Microbiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Faisal Hanif Department of Pathology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan
  • Javaid Usman Department of Pathology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.8582

Keywords:

Acquired immunodeficiency syndrome, Case report, Cryptococcus laurentii, Meningitis

Abstract

Infections caused by non-neoformans Cryptococcus spp., including Cryptococcus laurentii, previously thought to be saprophyte and non-pathogenic, have become more common during the past few years, particularly in immunocompromised hosts. To the best of our knowledge here, we present the first case of meningitis in an immunocompromised patient due to a fungus that has never been reported in Pakistan. Our patient, a 40-year old male, who had acquired immunodeficiency syndrome (AIDS) was diagnosed as Cryptococcus laurentti meningitis, with a rare neurological manifestation i.e., cryptococcomas and lepto-meningitis. We presume that exposure to pigeon droppings and acquired immunodeficiency syndrome were the risk factors for this case report. He was treated with liposomal Amphotericin (LAMB) and fluconazole but unfortunately, he rapidly deteriorated and ultimately succumbed to the infection. This case underscores the significance of prompt diagnosis and vigorous treatment of Cryptococcus laurentii meningitis, as well as the need for continued surveillance in immunocompromised individuals.

Author Biographies

Rafia Irfan, Department of Microbiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan

Consultant Microbiologist

Faisal Hanif, Department of Pathology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan

Associate professor of Pathology

Javaid Usman, Department of Pathology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan

Professor of Pathology

Published

2023-09-13

How to Cite

Zulfiqar, A., Rafia Irfan, Faisal Hanif, & Javaid Usman. (2023). Usual presentation of an unusual pathogen – Cryptococcus laurentii meningitis: a case report. Journal of the Pakistan Medical Association, 73(10), 2100–2102. https://doi.org/10.47391/JPMA.8582

Issue

Section

Case Report