Betibeglogene Autotemcel; A new hope for transfusion dependent beta-thalassaemia

Authors

  • Hiba Tariq Wally Department of Orthopaedic Surgery, Jinnah Postgraduate Medical Centre, Karachi, Pakistan https://orcid.org/0000-0001-8765-4776
  • Muhammad Hassan Zulfi Department of Orthopaedic Surgery, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
  • Elahi Sana Jilani Department of Orthopaedic Surgery, Jinnah Postgraduate Medical Centre, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.9532

Abstract

Respected Editor, Beta thalassaemia is an autosomal recessive disorder that leads to abnormal production of functional adult haemoglobin because of either inadequate or absent production of the B globin chain (beta+/beta0).1 Transfusion-dependent thalassemia (TDT) is a rare and most severe form requiring life-long blood transfusions. To mitigate the effects of TDT, life-long blood transfusions every 2-5 weeks are required, which can elicit transfusion-based reactions and lead to an iron overload state, which can further cause widespread organ damage despite the use of iron chelation therapy.2

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Published

2023-09-13

Issue

Section

Letter to the Editor