@article{Arslaan Javaeed_Sanniya Khan Ghauri_2020, title={Clinically-targetable vulnerabilities in cancer metabolism: A systematic review and meta-analysis}, url={https://ojs.jpma.org.pk/index.php/public_html/article/view/1622}, DOI={10.47391/JPMA.079}, abstractNote={<p><strong>Abstract</strong></p> <p><strong>Objectives</strong>: To investigate the efficacy and safety of targeting cancer metabolic vulnerabilities with specific anticancer agents.</p> <p><strong>Method</strong>: The systematic review and meta-analysis entailed search on PubMed, Embase and Google Scholar databases for cohort-based studies or clinical trials which reported hazard ratio for overall survival and/or median overall survival of patients treated with metabolically-active anticancer drugs. Data was analysed using the Number Cruncher Statistical System version 11.</p> <p><strong>Results</strong>: There were 16 studies published between 1989 and 2018 that reported improvement in the overall survival (p=0.05) despite the reported significant heterogeneity across the studies (I<sup>2</sup>=70%). Exploiting amino acid metabolic vulnerabilities was associated with a favourable prognostic outcome (p=0.05), while targeting glycolysis and nucleic acid synthesis had no significant clinical importance (p>0.05).</p> <p><strong>Conclusion</strong>: There is an urgent need to develop future therapies relying on the synergistic actions of nucleotide biosynthesis, glycolysis and amino acid metabolism.</p> <p><strong>Key Words:</strong> Metabolic vulnerabilities, Cancer, Chemotherapy, Cell metabolism, Metabolic enzymes.</p> <p><strong>Continuous...</strong></p> <p> </p>}, journal={Journal of the Pakistan Medical Association}, author={Arslaan Javaeed and Sanniya Khan Ghauri}, year={2020}, month={Oct.}, pages={1–37} }