@article{Sana Shahid_Asma Ladak_Syeda Sadia Fatima_Fatima Abid Zaidi_Sabah Farhat_2020, title={Association of vitamin D levels with preeclampsia}, url={https://ojs.jpma.org.pk/index.php/public_html/article/view/1676}, DOI={10.47391/JPMA.414}, abstractNote={<p><strong><u>Abstract</u></strong></p> <p><strong>Objectives:</strong> This study was aimed to assess maternal vitamin D status during pregnancy and  determine the association between maternal 25(OH) D levels with risk of preeclampsia (PE).</p> <p><strong>Methods: </strong>A cross-sectional study was conducted with 172 pregnant women recruited from JPMC between January and December 2017 who were divided as normotensive (n=80) and pre-eclamptic (n=92) groups. Blood pressure was recorded at 20 and 32 weeks of gestation. Five ml of blood sample was collected at 20 weeks of gestation to assess the vitamin D levels by commercially available ELISA assay.</p> <p><strong>Results:  </strong>PE group had a significantly higher systolic (p<0.001) and diastolic (p<0.001) blood pressure at 20 weeks of gestation. Vitamin D levels were reported to be significantly lower (p<0.001) in the PE group (17.97±9.38 ng/ml) as compared to normotensive group (42.18±25.17 ng/ml). A strong negative correlation of Vitamin D levels with systolic blood pressure (r=-0.428; p<0.001) and diastolic blood pressure (r= -0.375; p<0.001) was found.</p> <p><strong>Conclusion: </strong>This study found a strong relationship between low vitamin D levels and pre-eclamptic manifestation.</p> <p><strong>Keywords:</strong> Vitamin D; Pre-eclampsia; Pregnancy; Hypertension.</p> <p><strong>Continuous....</strong></p>}, journal={Journal of the Pakistan Medical Association}, author={Sana Shahid and Asma Ladak and Syeda Sadia Fatima and Fatima Abid Zaidi and Sabah Farhat}, year={2020}, month={Oct.} }