TY - JOUR AU - Ambreen Usmani, AU - Mehreen Lateef , PY - 2020/11/03 Y2 - 2024/03/28 TI - Evaluation of c-reactive protein in breast cancer by enzyme linked immunoassay technique JF - Journal of the Pakistan Medical Association JA - J Pak Med Assoc VL - 71 IS - 2 SE - Research Article DO - 10.47391/JPMA.297 UR - https://ojs.jpma.org.pk/index.php/public_html/article/view/1971 SP - 424-428 AB - <p><strong>Objective:</strong> To explore the serum levels of C-reactive protein in breast cancer patients, and to investigate the relationship between  inflammation and progression of breast cancer.</p><p><strong>Methods:</strong> The  case-control study  was conducted at Bahria University Medical and Dental College, Karachi, from September 2015 to December 2018, and comprised breast cancer patients in group A and and an equal number of age-matched healthy women in control group B. C-reactive protein levels were evaluated in serum samples using enzyme-linked immunosorbent assay in both the groups and micro ribonucleic acid levels in serum were quantified using real time polymerase chain reaction. Data was analysed using SPSS 16.</p><p><strong>Results:</strong> Of the 170 subjects, 85(50%) were in each of the two groups. C-reactive protein and micro ribonucleic acid expression were significantly different in group A (p&lt;0.001). There was no correlation (r = 0.162, p&gt;0.01) between the tumour  markers in  group B (p&gt;0.05).</p><p><strong>Conclusion:</strong> Significantly raised C-reactive protein levels showed there was a link between inflammation and breast cancer.</p><p><strong>Key Words:</strong> Breast cancer, C-reactive protein, MicroRNA 16. <strong>Continuous....</strong></p> ER -