TY - JOUR AU - Nadira Mamoon, AU - Hania Naveed, AU - Mariam Abid, AU - Humaira Nasir , AU - Imran Nazir Ahmad, AU - Zujajah Hameed , AU - Asna Haroon Khan, PY - 2020/11/03 Y2 - 2024/03/29 TI - Gastroenteropancreatic neuroendocrine tumors: clinicopathological evaluation at Shifa International Hospital, Islamabad. A single centre experience JF - Journal of the Pakistan Medical Association JA - J Pak Med Assoc VL - 71 IS - 2 SE - Audit DO - 10.47391/JPMA.835 UR - https://ojs.jpma.org.pk/index.php/public_html/article/view/1985 SP - 492-496 AB - <p><strong>Objective: </strong>Clinicopathological features of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have rarely been studied in the Pakistani population. We investigated the clinical characteristics of these tumors according to the updated World Health Organization (WHO) 2010 classification.</p><p><strong>Methods: </strong>The data of Shifa International Hospital, Islamabad was retrospectively analysed for pathologically confirmed GEP-NETs from January 2013 to March 2018.</p><p><strong>Results: </strong>One hundred and eighteen patients (mean age, 52.2 years; male, 55.1%) were identified. 83.1% of the patients were symptomatic including5.1% functional tumors. Pancreas (28%) was the most frequent primary site noted. The most common histologic type was well differentiated neuroendocrine tumor (WDNET) in 81.4% followed by neuroendocrine carcinoma (NEC) in 16.1%. 45.8% cases of WDNET were grade 1, 27.1% were grade 2, and 8.5% were grade 3.15.3% had distant metastasis at the time of diagnosis with liver (77.7%) as the most common metastatic site. Synaptophysin positivity was seen in 96.8% of grade 1 &amp; grade 2 WDNET, 100% of grade 3 WDNET and 92.3% of NEC and chromogranin was positive in 94.2% of grade 1 &amp;grade 2 WDNET, 83.3% of grade 3 WDNET and 45.4% of NEC.</p><p><strong>Conclusion: </strong>GEP-NETs showed a wide clinicopathological spectrum. Pancreas is the most site of involvement by the GEP-NET however grade 3 WDNET had a predilection for the colon. Small cell carcinomas were commonly observed in esophagus.</p><p><strong>Keywords: </strong>Gastroenteropancreatic neuroendocrine tu­mor, well differentiated neuroendocrine tumor, neuroendocrine carcinoma. <strong>Continuous...</strong></p> ER -